Thursday, July 31, 2025
White spot lesions represent the first clinical sign of dental caries and can be reversed using various remineralizing agents. This study aimed to synthesize different bioactive glass varnishes and assess their remineralizing effects on white spot lesions compared to fluoride varnish and a synthesized nanosilver fluoride varnish. Seventy-two extracted human teeth were used, divided into seven groups with varying varnish compositions. Statistical analysis using one-way and repeated measures ANOVA showed that the nanosilver-containing bioactive glass varnish (Group E) had the highest mineral gain percentage, followed by fluoride-containing bioactive glass (Group D) and nanosilver fluoride (Group F). Scanning electron microscopy revealed the development of new crystals in these groups, with bioactive glass varnishes showing comparable remineralizing efficacy to fluoride varnishes. The fluoride and nanosilver-containing bioactive glass varnishes demonstrated higher remineralizing potential compared to the standard fluoride varnish and nearly the same effect of the nanosilver fluoride varnish. Dental caries is the leading cause of dental pain and a chronic infectious disease, involving demineralization and remineralization processes. The white spot lesions, the earliest phase of enamel demineralization, can be repaired through remineralization. Bioactive glass materials, when exposed to body fluids, release calcium and phosphate ions, forming amorphous calcium phosphate (HA) and eventually hydroxyapatite (HA). Incorporating fluoride and silver nanoparticles into bioactive glass enhances remineralization activity, with silver nanoparticles showing superior bactericidal and anti-inflammatory properties. This study synthesizes bioactive glass varnishes and evaluates their remineralizing effects, highlighting the importance of bioactive glass in remineralizing dental caries.
Reference: Evaluation of the remineralization potential of different bioactive glass varnishes on white spot lesions: an in vitro studyLabels: BMC Oral Health
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